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Won't open PDF

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When I try to open a PDF whether on line or off my computer I get the following message; "There is a problem with Adobe Acrobat/Reader. If it is running, please exit and try again. (0:521)" I am running Windows 7 on a PC. I have Adobe Reader XI and it is up to date. I used to be able to open PDF files and now all of a sudden it won't. Suggestions?


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